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Article

Metabolic control analysis in drug discovery and disease.

Nature biotechnology - 1 Mar 2002

Cascante Marta, Boros Laszlo G, Comin-Anduix Begoña, de Atauri Pedro, Centelles Josep J, Lee Paul W-N

Abstract excerpt

Metabolic control analysis (MCA) provides a quantitative description of substrate flux in response to changes in system parameters of complex enzyme systems. Medical applications of the approach include the following: understanding the threshold effect in the manifestation of metabolic diseases; investigating the gene dose effect of aneuploidy in inducing phenotypic transformation in cancer; correlating the...

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PMID: 11875424
DOI: 10.1038/nbt0302-243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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