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Human Cytomegalovirus with IE-2 (UL122) Deleted Fails To Express Early Lytic Genes

15 Feb 2001

Abstract excerpt

Much evidence suggests that the major immediate-early (IE) transactivator of human cytomegalovirus (HCMV), IE-2, is likely to be critical for efficient viral replication; however, the lack of an IE-2 mutant HCMV has precluded an experimental test of this hypothesis. As an initial step toward characterizing an IE-2 mutant, we first cloned the HCMV Towne genome as a bacterial artificial chromosome (BAC) and...

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PMID: 11160686
DOI: 10.1128/jvi.75.4.1870-1878.2001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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