Article
Haptoglobin and the Th1/Th2 balance: hints from in vitro and in vivo studies.
Redox report : communications in free radical research - 1 Jan 2001
Arredouani M, Matthys P, Kasran A, Baumann H, Ceuppen J L
Abstract excerpt
A variety of immunomodulatory effects have previously been attributed to haptoglobin (Hp). These are supposed to be partly mediated through binding of Hp to CD11b. In the present study, we assessed its effects on T-helper (Th) cytokine production following both in vitro and in vivo stimulation of T-cells. Hp exhibits a dose-dependent inhibitory effect on human T lymphocyte release of the Th2 cytokines (IL-4,...
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