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Article

c-Myc Overexpression Uncouples DNA Replication from Mitosis

1 Aug 1999

Abstract excerpt

c-myc has been shown to regulate G(1)/S transition, but a role for c-myc in other phases of the cell cycle has not been identified. Exposure of cells to colcemid activates the mitotic spindle checkpoint and arrests cells transiently in metaphase. After prolonged colcemid exposure, the cells withdraw from mitosis and enter a G(1)-like state. In contrast to cells in G(1), colcemid-arrested cells have decreased G(1)...

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PMID: 10409725
DOI: 10.1128/mcb.19.8.5339

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