Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer.

doi:10.18632/oncotarget.2259

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Article

Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer.

Oncotarget - 30 Sept 2014

Yaglom Julia A, McFarland Christopher, Mirny Leonid, Sherman Michael Y

Abstract excerpt

DNA instability is an important contributor to cancer development. Previously, defects in the chromosome segregation and excessive DNA double strand breaks due to the replication or oxidative stresses were implicated in DNA instability in cancer. Here, we demonstrate that DNA instability can directly result from the oncogene-induced senescence signaling. Expression of the activated form of Her2 oncogene, NeuT, in...

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