Article
Sequence variations of the late upstream region of HPV16 in cervical intraepithelial neoplasm and invasive carcinoma.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Jan 2000
Pang T, Hu X, Ponten J
Abstract excerpt
HPV16 is the most common type of human papillomavirus (HPV) seen in cervical squamous cell carcinoma. A 78-bp promotor element at nt 4118-4196 called late upstream region (LUR), critical for the expression of late genes, has been identified recently. Late genes encode viral capsid proteins that coat viral DNA to form particles and serve as antigen. To elucidate whether there are any sequence variations within LUR...
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