Evolutionary fate of an unstable human minisatellite deduced from sperm-mutation spectra of individual alleles.

Abstract excerpt

Although mutation processes at some human minisatellites have been extensively characterized, the evolutionary fate of these unstable loci is unknown. Minisatellite instability is largely germline specific, with mutation rates up to several percent and with expansion events predominating over contractions. Using allele-specific small-pool polymerase chain reaction, we have determined sperm-mutation spectra of...

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