Article
N-acetyltransferase 2 polymorphism is not related to the risk of advanced alcoholic liver disease.
Scandinavian journal of gastroenterology - 1 Jan 2002
Agúndez J A G, Ladero J M, Olivera M, Lozano L, Fernández-Arquero M, de laConcha E G, Díaz-Rubio M, Benitez J
Abstract excerpt
BACKGROUND: Ethanol abuse is the most prevalent cause of liver cirrhosis in Spain. Genetic polymorphisms affect the activity of the enzymes involved in ethanol metabolism and in processing the toxic by-products generated in the liver. N-acetyltransferase 2 (NAT2) is a polymorphic phase 2 enzyme not involved in these processes, but recent data suggest that the most prevalent slow acetylator genotype protects...
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