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Article

Relationship between Cellular Oxygen Consumption and Atherosclerosis-associated Mitochondrial Mutations (Variants of the Mitochondrial Genome).

Current medicinal chemistry - 1 Jan 2026

Orekhov Alexander Nikolaevich, Sinyov Vasily Vladimirovich, Vyssokikh Mikhail Yurievich, Manukhova Ludmila, Marey Maria Vladimirovna, Angelova Plamena Rumyanova, Omelchenko Andrey Vladimirovich, Vinokurov Andrey Yurievich, Khasanova Zukhra B, Sobenin Igor Aleksandrovich

Abstract excerpt

BACKGROUND: Mitochondria are the main sites of cellular aerobic energy production through conjugation of respiration and oxidative phosphorylation. We have recently discovered mutations (genome variants) of mitochondrial DNA (mtDNA) associated with atherosclerosis. We have then investigated the possible mechanisms underlying such association and the role of mitochondrial mutations in atherogenesis. Mitochondrial...

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Identifiers

PMID: 38879762
DOI: 10.2174/0109298673302002240605092523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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