Article
Heterogeneous proliferative potential of occult metastatic cells in bone marrow of patients with solid epithelial tumors.
Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2002
Solakoglu Oender, Maierhofer Christine, Lahr Georgia, Breit Elisabeth, Scheunemann Peter, Heumos Isabella, Pichlmeier Uwe, Schlimok Gunter, Oberneder Ralph, Kollermann Manfred W, Kollermann Jens, Speicher Michael R, Pantel Klaus
Abstract excerpt
Bone marrow is a major homing site for circulating epithelial tumor cells. The present study was aimed to assess the proliferative capacity of occult metastatic cells in bone marrow of patients with operable solid tumors especially with regard to their clinical outcome. We obtained bone marrow aspirates from 153 patients with carcinomas of the prostate (n = 46), breast (n = 45), colon (n = 33), and kidney (n =...
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