Molecular Characterization of a Novel Class 1 Integron Containing <i>bla</i> _GES-1 and a Fused Product of <i>aac(3)-Ib/aac(6</i> " <i>)-Ib</i> " Gene Cassettes in <i>Pseudomonas aeruginosa</i>

Abstract excerpt

As seen by the disk diffusion method, the clinical strain of Pseudomonas aeruginosa Pa695, resistant to all extended-spectrum cephalosporins and aminoglycosides, exhibited an unusual synergistic effect between ceftazidime and imipenem. This isolate produced an extended-spectrum beta-lactamase (ESBL) with a pI of 5.8 that appeared to be chromosomally encoded. Cloning experiments revealed that this ESBL was encoded...

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