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Article

Regulation of corepressor function by nuclear NADH.

Science (New York, N.Y.) - 8 Mar 2002

Zhang Qinghong, Piston David W, Goodman Richard H

Abstract excerpt

The corepressor CtBP (carboxyl-terminal binding protein) is involved in transcriptional pathways important for development, cell cycle regulation, and transformation. We demonstrate that CtBP binding to cellular and viral transcriptional repressors is regulated by the nicotinamide adenine dinucleotides NAD+ and NADH, with NADH being two to three orders of magnitude more effective. Levels of free nuclear...

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Identifiers

PMID: 11847309
DOI: 10.1126/science.1069300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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