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Article

Role of NAD binding and catalytic residues in the C-terminal binding protein corepressor.

FEBS letters - 13 Nov 2007

Mani-Telang Priya, Sutrias-Grau Montserrat, Williams Geoffrey, Arnosti David N

Abstract excerpt

CtBP corepressor proteins potentiate the activity of many metazoan transcriptional repressors. These proteins are homologous to prokaryotic D-2-hydroxyacid dehydrogenases, possessing an NAD/NADH binding fold and conserved active site residues. When expressed in Drosophila, a catalytic site mutant...

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Identifiers

PMID: 17964573
DOI: 10.1016/j.febslet.2007.10.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17964573-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Role of NAD binding and catalytic residues in the C-terminal binding protein corepressor.PMID 17964573Read ↗

Conserved catalytic and C-terminal regulatory domains of the C-terminal binding protein corepressor fine-tune the transcriptional response in development.Semantic proximity Read ↗

CtBP contributes quantitatively to Knirps repression activity in an NAD binding-dependent manner.Semantic proximity Read ↗

Regulation of corepressor function by nuclear NADH.Semantic proximity Read ↗

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A basal transcription factor that activates or represses transcription.Semantic proximity Read ↗

CtBP1/BARS Gly172-->Glu mutant structure: impairing NAD(H)-binding and dimerization.Semantic proximity Read ↗

Changes in C-terminal binding protein 2 (CtBP2) corepressor complex induced by E1A and modulation of E1A transcriptional activity by CtBP2.Semantic proximity Read ↗

Functional knockout of the corepressor CtBP by the second exon of adenovirus E1a relieves repression of transcription.Semantic proximity Read ↗

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