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Article

Natural and pharmacological regulation of telomerase

15 Feb 2002

Abstract excerpt

The extremities of eukaryotic chromosomes are called telomeres. They have a structure unlike the bulk of the chromosome, which allows the cell DNA repair machinery to distinguish them from 'broken' DNA ends. But these specialised structures present a problem when it comes to replicating the DNA. Indeed, telomeric DNA progressively erodes with each round of cell division in cells that do not express telomerase, a...

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PMID: 11842096
DOI: 10.1093/nar/30.4.839

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