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Telomeres and Telomerase: Pharmacological Targets for New Anticancer Strategies?

28 Feb 2006

Abstract excerpt

Telomeres are located at the ends of eukaryotic chromosomes. Human telomerase, a cellular reverse transcriptase, is a ribonucleoprotein enzyme that catalyzes the synthesis and extension of telomeric DNA. It is composed of at least, a template RNA component (hTR; human Telomerase RNA) and a catalytic subunit, the telomerase reverse transcriptase (hTERT). The absence of telomerase is associated with telomere...

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PMID: 16529544
DOI: 10.2174/156800906776056482

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