Article
Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence.
Drug and alcohol dependence - 1 Feb 2002
Schmidt Lutz G, Samochowiec Jerzy, Finckh Ulrich, Fiszer-Piosik Ewa, Horodnicki Jan, Wendel B, Rommelspacher Hans, Hoehe Margret R
Abstract excerpt
Due to the involvement of the endogenous cannabinoid system in brain reward mechanisms a silent polymorphism (1359G/A; Thr453Thr) in the single coding exon of the CB1 human cannabinoid receptor gene (CNR1) was analysed in 121 severely affected Caucasian alcoholics and 136 most likely non-alcoholic controls. The observed frequency of the A allele was 31.2% for controls and 42.1% for alcoholics with severe...
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