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Paternal origins of complete hydatidiform moles proven by whole genome single-nucleotide polymorphism haplotyping.

Genomics - 1 Jan 2002

Fan Jian-Bing, Surti Urvashi, Taillon-Miller Patricia, Hsie Linda, Kennedy Giulia C, Hoffner Lori, Ryder Thomas, Mutch David G, Kwok Pui-Yan

Abstract excerpt

Complete hydatidiform moles (CHMs) are diploid tumors that result from fertilization of an empty ovum by a haploid 23,X sperm. In most cases, the resulting duplication of the genome gives rise to a 46,XX genotype and is thought to be androgenetic in origin. If this hypothesis is correct, then the genotypes of all polymorphic markers in CHMs should be homozygous. We used a dense set of single-nucleotide...

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Source

Identifiers

PMID: 11827458
DOI: 10.1006/geno.2001.6676

Genes

CHM

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