Article
Changes in gene expression and neuronal phenotype in brain stem pain modulatory circuitry after inflammation.
Journal of neurophysiology - 1 Feb 2002
Miki Kenji, Zhou Q-Q, Guo W, Guan Y, Terayama R, Dubner R, Ren K
Abstract excerpt
Recent studies indicate that descending pain modulatory pathways undergo time-dependent changes in excitability following inflammation involving both facilitation and inhibition. The cellular and molecular mechanisms of these phenomena are unclear. In the present study, we examined N-methyl-D-aspartate (NMDA) receptor gene expression and neuronal activity in the rostral ventromedial medulla (RVM), a pivotal...
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