Article
Leukemic predisposition of pSca-1/Cb2 transgenic mice.
Experimental hematology - 1 Feb 2002
Joosten Marieke, Valk Peter J M, Jordà Meritxell Alberich, Vankan-Berkhoudt Yolanda, Verbakel Sandra, van den Broek Marion, Beijen Antoinette, Löwenberg Bob, Delwel Ruud
Abstract excerpt
OBJECTIVE: The gene encoding the peripheral cannabinoid receptor Cb2 is located in the common virus integration site Evi11 and is associated with hematopoietic malignancies in mice. To determine the effect of Cb2 overexpression on hematopoietic development in vivo, Cb2 transgenic mice were generated. MATERIALS AND METHODS: A Cb2 expression vector was constructed containing a Cb2 cDNA fragment cloned into the 14kb...
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