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Article

Molecular analysis of hereditary deficiency of the third component of complement (C3) in two sisters.

Internal medicine (Tokyo, Japan) - 1 Dec 2001

Matsuyama W, Nakagawa M, Takashima H, Muranaga F, Sano Y, Osame M

Abstract excerpt

We report two sisters with hereditary deficiency of the third complement component (C3) and a homozygous mutation at C3303G (Tyr1081Stop) of the gene. They developed systemic lupus erythematosus-like symptoms during adolescence. Their C3 were not detected in serum immunochemically. Their mother and a brother had half of the normal C3 levels and a heterozygous mutation in the same position. Western blot analysis...

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Identifiers

PMID: 11813855
DOI: 10.2169/internalmedicine.40.1254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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