Article
Molecular analysis of the third component of canine complement (C3) and identification of the mutation responsible for hereditary canine C3 deficiency.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1998
Ameratunga R, Winkelstein J A, Brody L, Binns M, Cork L C, Colombani P, Valle D
Abstract excerpt
Genetically determined deficiency of the third component of complement (C3) in the dog is characterized by a predisposition to recurrent bacterial infections and to type 1 membranoproliferative glomerulonephritis. The current studies were undertaken to characterize the cDNA for wild-type canine C3 and identify the molecular basis for hereditary canine C3 deficiency. Amplification, cloning, and sequence analysis...
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