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Iron deficiency accelerates Helicobacter pylori–induced carcinogenesis in rodents and humans

21 Dec 2012

Abstract excerpt

Gastric adenocarcinoma is strongly associated with Helicobacter pylori infection; however, most infected persons never develop this malignancy. H. pylori strains harboring the cag pathogenicity island (cag+), which encodes CagA and a type IV secretion system (T4SS), induce more severe disease outcomes. H. pylori infection is also associated with iron deficiency, which similarly augments gastric cancer risk. To...

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PMID: 23257361
DOI: 10.1172/jci64373

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