Article
Complement activation induced by purified Neisseria meningitidis lipopolysaccharide (LPS), outer membrane vesicles, whole bacteria, and an LPS-free mutant.
The Journal of infectious diseases - 15 Jan 2002
Bjerre Anna, Brusletto Berit, Mollnes Tom Eirik, Fritzsønn Elisabeth, Rosenqvist Einar, Wedege Elisabeth, Namork Ellen, Kierulf Peter, Brandtzaeg Petter
Abstract excerpt
Complement activation is closely associated with plasma endotoxin levels in patients with meningococcal infections. This study assessed complement activation induced by purified Neisseria meningitidis lipopolysaccharide (Nm-LPS), native outer membrane vesicles (nOMVs), LPS-depleted outer membrane vesicles (dOMVs), wild-type meningococci, and an LPS-free mutant (lpxA(-)) from the same strain (44/76) in whole blood...
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