Article
Prolonged excretion of amantadine-resistant influenza a virus quasi species after cessation of antiviral therapy in an immunocompromised patient.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Mar 2002
Boivin Guy, Goyette Nathalie, Bernatchez Harold
Abstract excerpt
Phenotypic and molecular studies were conducted to characterize multiple influenza A isolates recovered from an immunocompromised patient who died of viral and fungal pneumonitis. The recovery of amantadine-resistant isolates was correlated with the detection of 2 drug-resistant M2 variants (codons 27 and 31) in combination with a wild-type virus. The mutant viruses persisted within the viral population in...
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