Article
The Drosophila melanogaster gene brain tumor negatively regulates cell growth and ribosomal RNA synthesis.
Development (Cambridge, England) - 1 Jan 2002
Frank Deborah J, Edgar Bruce A, Roth Mark B
Abstract excerpt
The regulation of ribosome synthesis is likely to play an important role in the regulation of cell growth. Previously, we have shown that the ncl-1 gene in Caenorhabditis elegans functions as an inhibitor of cell growth and ribosome synthesis. We now indicate that the Drosophila melanogaster tumor suppressor brain tumor (brat) is an inhibitor of cell growth and is a functional homolog of the C. elegans gene...
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