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Article

Analysis of astrovirus serotype 1 RNA, identification of the viral RNA-dependent RNA polymerase motif, and expression of a viral structural protein.

Journal of virology - 1 Jan 1994

Lewis T L, Greenberg H B, Herrmann J E, Smith L S, Matsui S M

Abstract excerpt

We report the results from sequence analysis and expression studies of the gastroenteritis agent astrovirus serotype 1. We have cloned and sequenced 5,944 nucleotides (nt) of the estimated 7.2-kb RNA genome and have identified three open reading frames (ORFs). ORF-3, at the 3' end, is 2,361 nt in length and is fully encoded in both the genomic and subgenomic viral RNAs. Expression of ORF-3 in vitro yields an...

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Identifiers

PMID: 8254779
DOI: 10.1128/JVI.68.1.77-83.1994
PMCID: PMC236266

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