Article
Development of resistance mutations to nevirapine as part of triple-drug therapy in children.
Pharmacotherapy - 1 Jan 2002
Seifert Lynn L
Abstract excerpt
Five children received nevirapine, a nonnucleoside reverse transcriptase inhibitor used as part of a triple-drug regimen to treat human immunodeficiency virus infection. They all developed resistance mutations to the agent within 4-10 months. They differed in compliance with drug therapy and development of specific mutations. Whether these mutations predict clinical resistance has yet to be determined.
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