Article
Linkage disequilibrium structure and its impact on the localization of a candidate functional mutation.
Genetic epidemiology - 1 Jan 2001
Huang Q, Morrison A C, Boerwinkle E
Abstract excerpt
We have used the unblinded MG1/Q1 Genetic Analysis Workshop 12 simulated data as a model system for investigating the use of linkage disequilibrium structure and simple genotype-phenotype associations to identify candidate functional mutations within a gene of interest. Analysis of the pattern of pairwise linkage disequilibrium indicated three groups of single-nucleotide polymorphisms for which the linkage...
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