Article
Cladistic analysis of haplotypes as an attempt to detect disease susceptibility.
Genetic epidemiology - 1 Jan 2001
Darlu P, Génin E
Abstract excerpt
We report the results of our analyses of the Genetic Analysis Workshop 12 simulated data set, using phylogenetic methods to reconstruct the history of haplotypes. We selected candidate gene 1 and 6, drawn from the isolate population. In a first step, haplotypes were inferred using family data. In a second step, cladistic approaches were performed to select the most parsimonious trees under various conditions of...
Topics
- Chromosome Mapping
- Genes, Dominant
- Genetic Predisposition to Disease
- Genetics, Population
- Haplotypes
- Humans
- Lod Score
- Models, Genetic
- Pedigree
- Penetrance
- Software
