Article
Up-regulation of WNT8B mRNA in human gastric cancer.
International journal of oncology - 1 Feb 2002
Saitoh Tetsuroh, Mine Tetsuya, Katoh Masaru
Abstract excerpt
WNT - beta-catenin - TCF signaling pathway is activated by Xenopus wnt-8 (Xwnt-8) during Xenopus early development, and dysregulated activation of beta-catenin - TCF signaling pathway in mammalian cells leads to carcinogenesis. We have previously cloned and characterized human WNT8A, one of human orthologues of Xwnt-8. Here, we cloned and characterized human WNT8B by using bioinformatics, cDNA-PCR, and RACE....
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