Article
Decay of HIV type 1 DNA and development of drug-resistant mutants in patients with primary HIV type 1 infection receiving highly active antiretroviral therapy.
AIDS research and human retroviruses - 20 Nov 2001
Riva E, Pistello M, Narciso P, D'Offizi G, Isola P, Galati V, Turriziani O, Tozzi V, Vincenzi L, Dianzani F, Antonelli G
Abstract excerpt
The present study was aimed at describing the effect of highly active antiretroviral therapy (HAART) in 10 patients with primary HIV infection (PHI). Clearance rates of HIV RNA and HIV DNA in peripheral blood as well as the preexistence and the emergence of drug-resistant strains of HIV were determined over 52 weeks of treatment. The data indicate that HAART is able to induce a suppression of plasma viral load...
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