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Inhibition of Interferons by Ectromelia Virus

1 Feb 2002

Abstract excerpt

Ectromelia virus (EV) is an orthopoxvirus (OPV) that causes mousepox, a severe disease of laboratory mice. Mousepox is a useful model of OPV infection because EV is likely to be a natural mouse pathogen, unlike its close relatives vaccinia virus (VV) and variola virus. Several studies have highlighted the importance of mouse interferons (IFNs) in resistance to and recovery from EV infection, but little is known...

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PMID: 11773388
DOI: 10.1128/jvi.76.3.1124-1134.2002

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