Article
[The significance of nucleotide repeat sequences in FVIII gene for detecting hemophilia A carriers].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 Oct 2001
Long G, Zhu C, Liu J
Abstract excerpt
OBJECTIVE: To detect the carriers in hemophilia A(HA) families by haplotype analysis of the microsatellite polymorphisms at intron 13 [13(CA)n] and 22[22(GT)n(AG)n] in the factor VIII (FVIII) gene. METHOD: Multi-PCR amplification of 13(CA)n and 22(GT)n(AG)n combined with silver staining were used. RESULTS: In 35 HA families, 11 had HA history. There were 21 female members in the 11 HA families and all of them...
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