Article
[Mutation screening of the F VIII gene in 10 hemophilia A families].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Apr 2011
LI Wen, HU Xiao, GAO Bo-di, LI Lu-yun, LIAO Yi, TANG Xue-mei, TANG Wei-lin, Lu Guang-xiu
Abstract excerpt
OBJECTIVE: To identify the F VIII gene mutations of patients and suspected female carriers in 10 Hemophilia A (HA) families, and to guide the prenatal diagnosis. METHODS: PCR, denaturinghigh performance liquid chromatogramphy (DHPLC) and DNA sequencing technologies were applied to screen the F VIII gene of 8 HA patients and 12 suspected female carriers in the 10 families. Linkage analysis was performed by using...
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