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Article

Hsp90 inhibition increases p53 expression and destabilizes MYCN and MYC in neuroblastoma

24 Nov 2010

Abstract excerpt

Neuroblastoma is a childhood cancer that exhibits either a favorable or an unfavorable phenotype. MYCN and MYC are oncoproteins that play crucial roles in determining the malignancy of unfavorable neuroblastoma. The Hsp90 superchaperone complex assists in the folding and function of a variety of oncogenic client proteins. Inhibition of Hsp90 by small molecule inhibitors leads to the destabilization of these...

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PMID: 21109931
DOI: 10.3892/ijo_00000829

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