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Article

Staphylococcus aureus sarA regulates inflammation and colonization during central nervous system biofilm formation.

PloS one - 1 Jan 2013

Snowden Jessica N, Beaver Matt, Beenken Karen, Smeltzer Mark, Horswill Alexander R, Kielian Tammy

Abstract excerpt

Infection is a frequent and serious complication following the treatment of hydrocephalus with CSF shunts, with limited therapeutic options because of biofilm formation along the catheter surface. Here we evaluated the possibility that the sarA regulatory locus engenders S. aureus more resistant to immune recognition in the central nervous system (CNS) based on its reported ability to regulate biofilm formation....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24386336
DOI: 10.1371/journal.pone.0084089
PMCID: PMC3875531

Genes

CXCL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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