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Article

A novel autoregulated proliferation-controlled production process using recombinant CHO cells.

Biotechnology and bioengineering - 20 Oct 1999

Mazur X, Eppenberger H M, Bailey J E, Fussenegger M

Abstract excerpt

Controlled proliferation bioprocesses have shown great enhancement of heterologous protein production. This novel technology has been implemented here using a multicistronic expression unit encoding the product gene and a cytostatic cell-cycle-arresting gene (p27) under control of a single tetracycline-repressible (tet(off)) promoter. The strict genetic linkage of both genes allows the dissection of the...

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PMID: 10458734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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