Article
Alternative splice variants of alpha 7 beta 1 integrin selectively recognize different laminin isoforms.
The Journal of biological chemistry - 22 Feb 2002
von der Mark Helga, Williams Inka, Wendler Olaf, Sorokin Lydia, von der Mark Klaus, Pöschl Ernst
Abstract excerpt
The integrin alpha(7)beta(1) occurs in several cytoplasmic (alpha(7A), alpha(7B)) and extracellular splice variants (alpha(7X1), alpha(7X2)), which are differentially expressed during development of skeletal and heart muscle. The extracellular variants result from the alternative splicing of exons X1 and X2, corresponding to a segment within the putative ligand binding domain. To study the specificity and...
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