Article
Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon.
The American journal of pathology - 1 Dec 2001
Hinoi T, Tani M, Lucas P C, Caca K, Dunn R L, Macri E, Loda M, Appelman H D, Cho K R, Fearon E R
Abstract excerpt
Most large bowel cancers are moderately to well-differentiated adenocarcinomas comprised chiefly or entirely of glands lined by tall columnar cells. We have identified a subset of poorly differentiated colon carcinomas with a distinctive histopathological appearance that we term large cell minimally differentiated carcinomas (LCMDCs). These tumors likely include a group of poorly differentiated carcinomas...
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