Article
K(+)-channel transgenes reduce K(+) currents in Paramecium, probably by a post-translational mechanism.
Genetics - 1 Nov 2001
Ling K Y, Haynes W J, Oesterle L, Kung C, Preston R R, Saimi Y
Abstract excerpt
PAK11 is 1 of more than 15 members in a gene family that encodes K(+)-channel pore-forming subunits in Paramecium tetraurelia. Microinjection of PAK11 DNA into macronuclei of wild-type cells results in clonal transformants that exhibit hyperexcitable swimming behaviors reminiscent of certain loss-of-K(+)-current mutants. PAK2, a distant homolog of PAK11, does not have the same effect. But PAK1, a close homolog of...
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