The cell wall-associated serine protease PrtA: a highly conserved virulence factor of<i>Streptococcus pneumoniae</i>

Abstract excerpt

The surface-associated subtilisin-like serine protease PrtA was identified by screening a genomic expression library from Streptococcus pneumoniae using a convalescent-phase serum. In Western blot analysis two forms of PrtA were detected in whole cell lysate and a truncated form only in culture supernatant suggesting that PrtA is produced as a precursor protein, translocated to the cell surface, truncated, and...

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