Article
Coenzyme Q10, exercise lactate and CTG trinucleotide expansion in myotonic dystrophy.
Brain research bulletin - 1 Jan 2000
Siciliano G, Mancuso M, Tedeschi D, Manca M L, Renna M R, Lombardi V, Rocchi A, Martelli F, Murri L
Abstract excerpt
Steinert's myotonic dystrophy (DM) is a genetic autosomal dominant disease and the most frequent muscular dystrophy in adulthood. Although causative mutation is recognized as a CTG trinucleotide expansion on 19q13.3, pathogenic mechanisms of multisystem involvement of DM are still under debate. It has been suggested that mitochondrial abnormalities can occur in this disease and deficiency of coenzyme Q 10 (CoQ10)...
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