Article
Coenzyme Q10 defects may be associated with a deficiency of Q10-independent mitochondrial respiratory chain complexes.
Biological research - 8 Jan 2016
Fragaki Konstantina, Chaussenot Annabelle, Benoist Jean-François, Ait-El-Mkadem Samira, Bannwarth Sylvie, Rouzier Cécile, Cochaud Charlotte, Paquis-Flucklinger Véronique
Abstract excerpt
BACKGROUND: Coenzyme Q10 (CoQ10 or ubiquinone) deficiency can be due either to mutations in genes involved in CoQ10 biosynthesis pathway, or to mutations in genes unrelated to CoQ10 biosynthesis. CoQ10 defect is the only oxidative phosphorylation disorder that can be clinically improved after oral CoQ10 supplementation. Thus, early diagnosis, first evoked by mitochondrial respiratory chain (MRC)...
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