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Article

Phenotypic effects of expanded ataxin-1 polyglutamines with interruptions in vitro.

Brain research bulletin - 1 Jan 2000

Calabresi V, Guida S, Servadio A, Jodice C

Abstract excerpt

Spinocerebellar ataxia type 1 is a neurodegenerative disease caused by expansion of an uninterrupted glutamine repeat in ataxin-1 protein. Protein aggregation and immunoreactivity to 1C2 monoclonal antibody are two distinct pathognomonic features of expanded ataxin-1, as well as of other polyglutamine disorders. Rare cases of non-affected elderly subjects carrying expanded ataxin-1 alleles were found in random...

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PMID: 11719269
DOI: 10.1016/s0361-9230(01)00600-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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