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Article

Characterization and purification of a mammalian endoribonuclease specific for the alpha -globin mRNA.

The Journal of biological chemistry - 25 Jan 2002

Rodgers Nancy D, Wang Zuoren, Kiledjian Megerditch

Abstract excerpt

The alpha-globin mRNA has previously been shown to be the target of an erythroid-enriched endoribonuclease (ErEN) activity which cleaves the mRNA within the 3'-untranslated region. We have currently undertaken a biochemical approach to purify this enzyme and have begun characterization of the enzyme to determine requirements for substrate recognition as well as optimal cleavage conditions. Through mutational...

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PMID: 11711537
DOI: 10.1074/jbc.M108330200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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