Evaluation of a Tetracycline-Inducible Promoter in <i>Staphylococcus aureus</i> In Vitro and In Vivo and Its Application in Demonstrating the Role of <i>sigB</i> in Microcolony Formation

Abstract excerpt

An inducible promoter system provides a powerful tool for studying the genetic basis for virulence. A variety of inducible systems have been used in other organisms, including pXyl-xylR-inducible promoter, the pSpac-lacI system, and the arabinose-inducible P(BAD) promoter, but each of these systems has limitations in its application to Staphylococcus aureus. In this study, we demonstrated the efficacy of a...

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