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Article

Loss-of-function mutations in yjbD result in ClpX- and ClpP-independent competence development of Bacillus subtilis.

Molecular microbiology - 1 Oct 2001

Nakano M M, Hajarizadeh F, Zhu Y, Zuber P

Abstract excerpt

Mutations in clpP and clpX have pleiotropic effects on growth and developmentally regulated gene expression in Bacillus subtilis. ClpP and ClpX are needed for expression of comK, encoding the competence transcription factor required for the expression of genes within the competence regulon. ClpP, in combination with the ATPase ClpC, degrades the inhibitor of ComK, MecA. Proteolysis of MecA is stimulated by a...

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PMID: 11703662
DOI: 10.1046/j.1365-2958.2001.02639.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss-of-function mutations in yjbD result in ClpX- and ClpP-independent competence development of Bacillus subtilis.PMID 11703662Read ↗

Spx (YjbD), a negative effector of competence in Bacillus subtilis, enhances ClpC-MecA-ComK interaction.Semantic proximity Read ↗

ClpP of Bacillus subtilis is required for competence development, motility, degradative enzyme synthesis, growth at high temperature and sporulation.Semantic proximity Read ↗

Competence in Bacillus subtilis is controlled by regulated proteolysis of a transcription factor.Semantic proximity Read ↗

MecB of Bacillus subtilis, a member of the ClpC ATPase family, is a pleiotropic regulator controlling competence gene expression and growth at high temperature.Semantic proximity Read ↗

Multiple pathways of Spx (YjbD) proteolysis in Bacillus subtilis.Semantic proximity Read ↗

Involvement of ClpX protein in the post-transcriptional regulation of a competence specific transcription factor, ComK protein, of Bacillus subtilis.Semantic proximity Read ↗

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The Bacillus subtilis late competence operon comE is transcriptionally regulated by yutB and under post-transcription initiation control by comN (yrzD).Semantic proximity Read ↗

Mutations conferring amino acid residue substitutions in the carboxy-terminal domain of RNA polymerase alpha can suppress clpX and clpP with respect to developmentally regulated transcription in Bacillus subtilis.Semantic proximity Read ↗

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The bdbDC operon of Bacillus subtilis encodes thiol-disulfide oxidoreductases required for competence development.Semantic proximity Read ↗

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