Transmembrane signalling by the chimeric chemosensory receptors of Escherichia coli Tsr and Tar with heterologous membrane-spanning regions.

doi:10.1111/j.1365-2958.1994.tb01312.x

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Article

Transmembrane signalling by the chimeric chemosensory receptors of Escherichia coli Tsr and Tar with heterologous membrane-spanning regions.

Molecular microbiology - 1 Nov 1994

Tatsuno I, Lee L, Kawagishi I, Homma M, Imae Y

Abstract excerpt

The serine and aspartate chemosensory receptors (Tsr and Tar) of Escherichia coli have two membrane-spanning regions TM1 and TM2. To investigate their roles in transmembrane signalling, we constructed two chimeric receptors from Tsr and Tar with heterologous combinations of TM1 and TM2: the N-terminus of one receptor, including TM1 and the periplasmic domain, was fused to the C-terminus of the other, beginning...

Topics

Adaptation, Physiological
Aspartic Acid
Bacterial Proteins
Chemoreceptor Cells
Chemotaxis
Cytoplasm
Escherichia coli
Escherichia coli Proteins
Genes, Bacterial
Hydrogen-Ion Concentration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Methylation

Mutation

Receptors, Cell Surface

Recombinant Fusion Proteins

Serine

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 7891561
DOI: 10.1111/j.1365-2958.1994.tb01312.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7891561-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Transmembrane signalling by the chimeric chemosensory receptors of Escherichia coli Tsr and Tar with heterologous membrane-spanning regions.PMID 7891561Read ↗

Inversion of thermosensing property of the bacterial receptor Tar by mutations in the second transmembrane region.Semantic proximity Read ↗

Ligand specificity determined by differentially arranged common ligand-binding residues in bacterial amino acid chemoreceptors Tsr and Tar.Semantic proximity Read ↗

Signaling by the Escherichia coli aspartate chemoreceptor Tar with a single cytoplasmic domain per dimer.Semantic proximity Read ↗

Role of threonine residue 154 in ligand recognition of the tar chemoreceptor in Escherichia coli.Semantic proximity Read ↗

Attractant signaling by an aspartate chemoreceptor dimer with a single cytoplasmic domain.Semantic proximity Read ↗

Conformational suppression of inter-receptor signaling defects.Semantic proximity Read ↗

Strategies for differential sensory responses mediated through the same transmembrane receptor.Semantic proximity Read ↗

Different signaling roles of two conserved residues in the cytoplasmic hairpin tip of Tsr, the Escherichia coli serine chemoreceptor.Semantic proximity Read ↗

Residues at the cytoplasmic end of transmembrane helix 2 determine the signal output of the TarEc chemoreceptor.Semantic proximity Read ↗

Mutational analysis of N381, a key trimer contact residue in Tsr, the Escherichia coli serine chemoreceptor.Semantic proximity Read ↗

Sensing of cytoplasmic pH by bacterial chemoreceptors involves the linker region that connects the membrane-spanning and the signal-modulating helices.Semantic proximity Read ↗

Intragenic suppressors of a mutation in the aspartate chemoreceptor gene that abolishes binding of the receptor to methyltransferase.Semantic proximity Read ↗

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