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Article

Association of mutations in the hemochromatosis gene with shorter life expectancy.

Archives of internal medicine - 12 Nov 2001

Bathum L, Christiansen L, Nybo H, Ranberg K A, Gaist D, Jeune B, Petersen N E, Vaupel J, Christensen K

Abstract excerpt

BACKGROUND: To investigate whether the frequency of carriers of mutations in the HFE gene associated with hereditary hemochromatosis diminishes with age as an indication that HFE mutations are associated with increased mortality. It is of value in the debate concerning screening for hereditary hemochromatosis to determine the significance of heterozygosity. METHODS: Genotyping for mutations in exons 2 and 4 of...

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Source

Identifiers

PMID: 11700156
DOI: 10.1001/archinte.161.20.2441

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of mutations in the hemochromatosis gene with shorter life expectancy.PMID 11700156Read ↗

Penetrance of 845G--> A (C282Y) HFE hereditary haemochromatosis mutation in the USA.Semantic proximity Read ↗

Penetrance, cancer incidence and survival in HFE haemochromatosis-A population-based cohort study.Semantic proximity Read ↗

Haemochromatosis-associated HFE genotypes in English blood donors: age-related frequency and biochemical expression.Semantic proximity Read ↗

HFE mutations in the elderly.Semantic proximity Read ↗

No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus study.Semantic proximity Read ↗

Correlation between iron status and genetic hemochromatosis (codon C282Y) in a large German population.Semantic proximity Read ↗

HFE genotypes, haemochromatosis diagnosis and clinical outcomes at age 80 years: a prospective cohort study in the UK Biobank.Semantic proximity Read ↗

HFE genotype and parameters of iron metabolism in German first-time blood donors - evidence for an increased transferrin saturation in C282Y heterozygotes.Semantic proximity Read ↗

Heterozygosity for the C282Y mutation in the hemochromatosis gene is associated with increased serum iron, transferrin saturation, and hemoglobin in young women: a protective role against iron deficiency?Semantic proximity Read ↗

Penetrance of the C28Y/C282Y genotype of the HFE gene.Semantic proximity Read ↗

High prevalence of the hemochromatosis-associated Cys282Tyr HFE gene mutation in a healthy Norwegian population in the city of Oslo, and its phenotypic expression.Semantic proximity Read ↗

Morbidity, risk of cancer and mortality in 3645 HFE mutations carriers.Semantic proximity Read ↗

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