Article
The risk of antibody formation against HNA1a and HNA1b granulocyte antigens during pregnancy and its relation to neonatal neutropenia.
Transfusion medicine (Oxford, England) - 1 Oct 2001
Zupańska B, Uhrynowska M, Guz K, Maślanka K, Brojer E, Czestyńska M, Radomska I
Abstract excerpt
The evaluation of immunization by the HNA1a and 1b antigens during pregnancy was based on (i) their genotyping in 1038 unselected mothers and newborns of homozygous mothers, (ii) granulocyte counting in all born infants and (iii) examination of granulocyte antibodies in maternal sera if an HNA1 incompatibile child was born. A total of 548 (52.8%) mothers were heterozygous--thus further examinations were not done....
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